Etymology

acanthosis

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Today it means: A benign abnormal thickening of the stratum spinosum, or prickle cell, layer of the epidermis. Full definition →

First used First attested in the late 19th century.
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The story

From acanth- + -osis (“diseased condition”).

First known use, by meaning

  • First attested in the late 19th century. A benign abnormal thickening of the stratum spinosum, or prickle cell, layer of the epidermis.

Etymology from Wiktionary, CC BY-SA 4.0.