Etymology

bone hurting juice

Today it means: A genre of Internet meme where the text of an original image, typically a webcomic, is altered to replace or remove the punch line. Full definition →

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The story

From the first example of this type of meme showing Tigger exclaiming that instead of drinking honey, Winnie-the-Pooh is drinking "bone hurting juice", which makes his bones hurt.

Etymology from Wiktionary, CC BY-SA 4.0.