Etymology

botheration

bo·ther·a·tion
B3O1T1H4E1R1A1T1I1O1N1

Today it means: A mild expression of annoyance or exasperation: bother! Full definition →

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The story

From bother + -ation (suffix indicating an action or process, or its result).

Etymology from Wiktionary, CC BY-SA 4.0.