Etymology

elephant's toothpaste

Today it means: A foamy substance caused by the rapid decomposition of hydrogen peroxide using potassium iodide as a catalyst; the outcome of a popular educational experiment in chemistry. Full definition →

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The story

The foamy texture and size of the resulting mass suggest a large amount of toothpaste, as might be imagined to be used by a large creature like an elephant.

Etymology from Wiktionary, CC BY-SA 4.0.