The story
From a 1987 episode of the British television comedy Blackadder, in which Dr. Samuel Johnson boasts about his newly completed dictionary containing every word in the English language. Blackadder subsequently uses a number of newly-invented words to perplex him: "I'm anaspeptic, frasmotic, even compunctuous to have caused you such pericombobulation."
Etymology from Wiktionary, CC BY-SA 4.0.