Etymology

gird up one's loins

Today it means: To prepare oneself for something demanding. Full definition →

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The story

Likely a Hebraism, often used in the King James Bible (e.g., 2 Kings 4:29). Literally referred to the need to strap a belt around one's waist, i.e. when getting up, in order to avoid the cloak falling off; or otherwise before battle, to free the legs for running.

Etymology from Wiktionary, CC BY-SA 4.0.