Etymology

give a monkey's

Today it means: To care; to have an interest or concern. Full definition →

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The story

Possibly a euphemistic ellipsis of “to give a monkey's toss”, “to give a monkey's shit”, "to give a monkey's fart", or “to give a monkey's arse”; compare give a rat's arse or give a rat's ass.

Etymology from Wiktionary, CC BY-SA 4.0.