Etymology

helix-turn-helix

Today it means: A structural motif where two alpha helices are joined by a short amino acid loop, frequently acting as a DNA binding site. Full definition →

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The story

From helix + turn + helix. The term got its name from its distinct physical geometry; two alpha helices separated by a short amino acid sequence connecting the helices, where one helix recognizes and binds to a specific sequence in DNA.

Etymology from Wiktionary, CC BY-SA 4.0.