Etymology

louping ill

Today it means: An enzootic and often fatal viral disease of sheep and other domestic animals, spread by ticks. It is characterized by muscular tremors and spasms, followed by more or less complete paralysis. The principal lesion is an inflammation of the membranes covering the brain and spinal cord. Full definition →

Scots loup
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The story

  1. Scots · derived fromloup“to leap”
  2. English todaylouping ill

From Scots loup (“to leap”), since affected sheep would spring into the air.

Etymology from Wiktionary, CC BY-SA 4.0.