Etymology

spike someone's guns

Today it means: To frustrate a person's efforts or designs; to undercut, to render helpless. Full definition →

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The story

From the wartime practice of welding a metal spike into the touch hole of a cannon (generally done to enemy guns by raiders, or to one's own guns if forced to abandon them in a retreat), making the cannon impossible to fire.

Etymology from Wiktionary, CC BY-SA 4.0.