Etymology

those who say it cannot be done should not interrupt those doing it

Today it means: People who dispute that a task is possible should not impede those people who attempt to do it. Full definition →

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The story

Possibly from a Chicago newspaper in 1903: “Things move along so rapidly nowadays that people saying: ‘It can’t be done,’ are always being interrupted by somebody doing it.” https://www.nytimes.com/2018/06/12/world/asia/ivanka-trump-china-summit-korea.html

Etymology from Wiktionary, CC BY-SA 4.0.