Etymology

up so down

Middle English up-so-doun
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The story

  1. Middle English · inherited fromup-so-doun
  2. English todayup so down

From Middle English up-so-doun, upsedowne, upsadowne (“upside down”); equivalent to up + so + down, literally “up as down”.

Etymology from Wiktionary, CC BY-SA 4.0.