The story
From the novel You Can't Go Home Again by Thomas Wolfe (1900–1938), published posthumously in 1940. Wolfe took the title from a conversation with the writer Ella Winter, who remarked to Wolfe: "Don't you know you can't go home again?" Wolfe then asked Winter for permission to use the phrase as the title of his book.
Etymology from Wiktionary, CC BY-SA 4.0.