Benadryl

B3E1N1A1D2R1Y4L1
/ˈbɛnədɹɪl/

noun

An antihistamine medication used to stop allergies or as a sleep aid.

UncommonScrabble 14

Meanings

nounBenadryl (countable and uncountable, plural Benadryls)

plural Benadryls

  1. countableuncountableAn antihistamine medication used to stop allergies or as a sleep aid.

    The Benadryl was for sleep, not allergies. I'd been having this thing where I woke up every night at two a.m.

    2024, Miranda July, All Fours, Canongate Books, →ISBN
    3 more examples

    The “Benadryl challenge”, wherein participants took a large amount of antihistamines in an attempt to produce hallucinogenic effects, led to at least one death.

    2022 October 30, Kari Paul, “What TikTok does to your mental health: ‘It’s embarrassing we know so little’”, in The Guardian, →ISSN

    Reading his posts as posted, sitting in my NOBE studio, railing Benadryls, getting progressively less attractive to ex bae due to domestic overexposure, I was rapt.

    2022, Sean Thor Conroe, Fuccboi, Hachette, →ISBN

    Benadryl, ZzzQuil and other drugs with diphenhydramine can also make you drowsy, since histamine helps the brain stay alert, said Dr. Zachary Rubin, an Illinois-based allergist and author of the upcoming book, “All About Allergies.”

    2025 July 15, Simar Bajaj, “Does Benadryl Do More Harm Than Good?”, in The New York Times, →ISSN

Synonyms & antonyms

nounantihistamine (trade name Benadryl) used to treat allergic reactions involving the nasal passages (hay fever) and also to treat motion sickness

Synonym sets from Open English WordNet, CC BY 4.0.

Origin

Cite this entry
APA

Benadryl. (n.d.). In WatkinsX Dictionary. Retrieved November 2, 2026, from https://dictionary.watkinsx.com/word/Benadryl

MLA

“Benadryl.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/Benadryl. Accessed November 2, 2026.

Chicago

WatkinsX Dictionary, s.v. “Benadryl,” accessed November 2, 2026, https://dictionary.watkinsx.com/word/Benadryl.

Source: Benadryl on Wiktionary, CC BY-SA 4.0.