Lesch-Nyhan syndrome

noun

A rare inherited genetic disorder, caused by a deficiency of HGPRT, in which uric acid builds up in all body fluids.

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Meanings

nounLesch-Nyhan syndrome (uncountable)
  1. uncountableA rare inherited genetic disorder, caused by a deficiency of HGPRT, in which uric acid builds up in all body fluids.

Origin

First clinically characterized by medical student Michael Lesch and his mentor, pediatrician William Nyhan, who published their findings in 1964.

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Cite this entry
APA

Lesch-Nyhan syndrome. (n.d.). In WatkinsX Dictionary. Retrieved November 5, 2026, from https://dictionary.watkinsx.com/word/Lesch-Nyhan%20syndrome

MLA

“Lesch-Nyhan syndrome.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/Lesch-Nyhan%20syndrome. Accessed November 5, 2026.

Chicago

WatkinsX Dictionary, s.v. “Lesch-Nyhan syndrome,” accessed November 5, 2026, https://dictionary.watkinsx.com/word/Lesch-Nyhan%20syndrome.

Source: Lesch-Nyhan syndrome on Wiktionary, CC BY-SA 4.0.