PSSD

P3S1S1D2

A form of post-SSRI sexual dysfunction — A permanent condition of physical and psychological sexual anhedonia, among other symptoms, that occurs in around 1 in 200 people who have consumed SRI drugs (SSRIs, SNRIs, etcetera), which is caused by the permanent desensitization of some serotonin receptors.

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Meanings

nounPSSD (plural PSSDs)

plural PSSDs

  1. abbreviationinitialismmedicineInitialism of post-SSRI sexual dysfunction.

    I've since discovered this side-effect isn't uncommon and has a name: PSSD (post-SSRI sexual dysfunction). I know men who also suffer with PSSD and struggle with the same genital numbness and anorgasmia, coupled with erectile dysfunction.

    2018 June 8, anonymous author, “My life in sex: ‘After taking antidepressants, my genitals felt numb’”, in The Guardian
  2. abbreviationinitialismbusinessInitialism of portable SSD.

Synonyms & antonyms

Also see
post-ssri sexual dysfunction
Cite this entry
APA

PSSD. (n.d.). In WatkinsX Dictionary. Retrieved November 4, 2026, from https://dictionary.watkinsx.com/word/PSSD

MLA

“PSSD.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/PSSD. Accessed November 4, 2026.

Chicago

WatkinsX Dictionary, s.v. “PSSD,” accessed November 4, 2026, https://dictionary.watkinsx.com/word/PSSD.

Source: PSSD on Wiktionary, CC BY-SA 4.0.