alcohol clamp

plural alcohol clamps

1. medicineA research procedure where ethanol is administered intravenously in order to keep a constant blood alcohol concentration over time.

   The alcohol clamp was developed to allow researchers to maintain a target BrAC in study participants despite these factors.

   2006, Vijay A Ramchandani, Sean O’Connor, “Studying alcohol elimination using the alcohol clamp method”, in Alcohol Res Health, volume 29, number 4, →PMID, →PMCID

   2 more examples

   This study characterizes a method for maintaining steady-state blood alcohol levels over several hours in the rat, referred to as the "alcohol clamp."

   2001 March, J C Froehlich, R B Stewart, T K Li, A K Mosemiller, D E McCullough, M C Ho, J M Kisner, “Induction of steady-state blood alcohol levels: application to the study of within-session alcohol tolerance in rats”, in Alcohol Clin Exp Res, volume 25, number 3, →PMID, page 370

   An alcohol clamp method combined with physiologically based pharmacokinetic (PBPK) modeling is more suitable since this can achieve fine control over the rate, magnitude, and duration of exposure to alcohol within a range of 0.05 mg/mL.

   2025 Mar, Sakiko Tsugawa, Fumihiko Ueno, Mutsuki Sakuma, Hideaki Tani, Ryo Ochi, Ariel Graff-Guerrero, Yoshihiro Noda, Hiroyuki Uchida, Masaru Mimura, Shunji Oshima, Sachio Matsushita, Shinichiro Nakajima, “Effects of short-term exposure to moderate amounts of alcohol on brain volume”, in Neuropsychopharmacol Rep, volume 45, number 1, →DOI, →PMID, →PMCID