cortisol

C3O1R1T1I1S1O1L1
UK/ˈkɔː.tɪ.sɒl/US/ˈkoɹ.tɪˌsɔl/US[ˈkoɹ.ɾɪˌsɔl]US, cot caught merger, dialectal/ˈkoɹ.tɪˌsɑl/

noun

A glucocorticoid steroid hormone produced by the adrenal cortex that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress.

Similar
hydrocortisoneHydrocortoneCortef
Less commonScrabble 10

Meanings

nouncortisol (countable and uncountable, plural cortisols)

plural cortisols

  1. countableuncountablesteroidsbiochemistryA glucocorticoid steroid hormone produced by the adrenal cortex that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress.

    “While chronic stress can lead to increased levels of cortisol in the body, those levels don’t usually rise high enough to create a moon face,” said dermatologist Dr. Rajani Katta, a clinical assistant professor at the Baylor College of Medicine in Houston.

    2024 October 17, Sandee LaMotte, “Stress and ‘moon face’: What experts say about this TikTok trend”, in CNN, archived from the original on 20 Oct 2024
    1 more example

    There is experimental evidence showing that cortisol restrains the intensity and duration of the emergency reaction to stress, and catecholamines have been shown to enhance emotional memory in the amygdala (see subsection on "Noradrenaline"). Thus, individuals lacking cortisol would overstore traumatic memories .

    2006, Marcus Lira Brandão, Frederico Guilherme Graeff, Neurobiology of Mental Disorders, page 36

    Synonyms: hydrocortisone

  2. InternetcountableuncountableStress.

Synonyms & antonyms

nounA glucocorticoid steroid hormone produced by the adrenal cortex that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress.

More synonyms by meaning

nounan adrenal-cortex hormone (trade names Hydrocortone or Cortef) that is active in carbohydrate and protein metabolism

Similar
hydrocortisoneHydrocortoneCortef
Broader
corticosteroidcorticoidadrenal cortical steroid

Synonym sets from Open English WordNet, CC BY 4.0.

Origin

  1. Proto-Indo-European*(s)ker-
  2. Proto-Indo-European*(s)kert-
  3. Proto-Indo-European*(s)kort-ek-s
  4. Latincortex
  5. Englishcortico-
  6. Proto-Indo-European*ǵʰelh₃-
  7. Proto-Hellenic*kʰolā́
  8. Ancient Greekχολή (kholḗ)
  9. Proto-Indo-European*ster-
  10. Ancient Greekστερεός (stereós)
  11. Frenchcholestérine
  12. Frenchcholestéro
  13. Englishcholesterol
  14. Englishsterol
  15. GermanKeton
  16. Englishketone
  17. Englishcorticosterone
  18. Englishcortisone
  19. Akkadian𒎎𒋆𒁉𒍣𒁕 (guḫlum)
  20. Aramaicכוחלא (kuḥlā)
  21. Arabicكُحْل (kuḥl)
  22. Andalusian Arabicكُحُول (kuḥūl)
  23. Medieval Latinalcoho
  24. Middle Englishalcofol
  25. Englishalcohol
  26. Englishcortisol

From cortisone + -ol.

Full word history & related roots →

Translations

Arabic كُورْتِيزُول
  • كُورْتِيزُول (kūrtīzūl)steroid hormone
Catalan cortisol
  • cortisolsteroid hormone
Chinese Mandarin 皮質醇 /皮质醇
  • 皮質醇 /皮质醇 (pízhìchún)steroid hormone
Czech kortizol
  • kortizolsteroid hormone
Finnish kortisoli
  • kortisolisteroid hormone
French cortisol
  • cortisolsteroid hormone
German Cortisol
  • Cortisolsteroid hormone
Hungarian kortizol
  • kortizolsteroid hormone
Italian cortisolo
  • cortisolosteroid hormone
Polish kortyzol
  • kortyzolsteroid hormone
Portuguese cortisol
  • cortisolsteroid hormone
Russian кортизол
  • кортизол (kortizol)steroid hormone
Slovak kortizol
  • kortizolsteroid hormone
Spanish cortisol
  • cortisolsteroid hormone
Swedish kortisol
  • kortisolsteroid hormone

Rhymes & wordplay

Anagrams

Cite this entry
APA

cortisol. (n.d.). In WatkinsX Dictionary. Retrieved November 3, 2026, from https://dictionary.watkinsx.com/word/cortisol

MLA

“cortisol.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/cortisol. Accessed November 3, 2026.

Chicago

WatkinsX Dictionary, s.v. “cortisol,” accessed November 3, 2026, https://dictionary.watkinsx.com/word/cortisol.

Source: cortisol on Wiktionary, CC BY-SA 4.0.