crosspeaks

Interestingly, the well-dispersed crosspeaks arising from the TTAI-bound state appear to have narrower linewidths than those from the apo-state, suggesting that the binding of TTAI reduces the overall conformational lability of the protein, which is consistent with the increased kinetic stability revealed by the IM-MS data.

2015 July 14, Mun Peak Nyon et al., “An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding”, in Protein Science : A Publication of the Protein Society, volume 24, →DOI