deimmunization

Mutations were restricted to those specified in the deimmunization prior, though all side-chains were allowed to change rotameric conformation in the search for low energy enzyme designs predicted to maintain the parental enzyme’s antibacterial activity.

2015 June 17, Kristina Blazanovic et al., “Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance”, in Molecular Therapy. Methods & Clinical Development, volume 2, →DOI