estradiol

E1S1T1R1A1D2I1O1L1
US/ˌɛs.tɹəˈdaɪˌɔl/

noun

A natural estrogenic hormone that is a phenolic alcohol estra-1,3,5-triene-3,17-diol (C₁₈H₂₄O₂) secreted chiefly by the ovaries of all vertebrates, that is a major and the most potent of the naturally occurring estrogens; the semisynthetic esterified compound is used medicinally to treat estrogen deficiency and breast cancer.

Similar
oestradiol
Less commonScrabble 10
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Meanings

nounestradiol (countable and uncountable, plural estradiols, abbreviation E2)

plural estradiols · abbreviation E2 · alternative UK oestradiol

  1. UScountableuncountablebiochemistryA natural estrogenic hormone that is a phenolic alcohol estra-1,3,5-triene-3,17-diol (C₁₈H₂₄O₂) secreted chiefly by the ovaries of all vertebrates, that is a major and the most potent of the naturally occurring estrogens; the semisynthetic esterified compound is used medicinally to treat estrogen deficiency and breast cancer.

    Gender-affirming hormone therapy may involve testosterone for trans people assigned female at birth (AFAB) and estradiol and anti-androgens for trans people AMAB.

    2021, Jane Y. Xu, Michelle A. O’Connell, Lauren Notini, Ada S. Cheung, Sav Zwickl, Ken C. Pang, “Selective Estrogen Receptor Modulators: A Potential Option For Non-Binary Gender-Affirming Hormonal Care?”, in Front Endocrinol, →DOI

Synonyms & antonyms

nounthe most powerful female hormone that occurs naturally; synthesized and used to treat estrogen deficiency and breast cancer

Similar
oestradiol
Broader
estrogenoestrogen
Also see
dihydrotheelinoestradiol

Synonym sets from Open English WordNet, CC BY 4.0.

Origin

Internationalism. From estratriene (“estra(triene)”) + diol. By surface analysis, estra- + di- + -ol.

Full word history & related roots →

Translations

Arabic إِسْتْرَادِيوُل
  • إِسْتْرَادِيوُل (ʔistrādīwul)Translations
Chinese Mandarin 雌二醇
  • 雌二醇 (cí'èrchún)Translations
Czech estradiol
  • estradiolTranslations
Finnish estradioli
  • estradioliTranslations
French oestradiol, estradiol
  • oestradiolTranslations
  • estradiolTranslations
German Östradiol
  • ÖstradiolTranslations
Italian estradiolo
  • estradioloTranslations
Japanese エストラジオール
  • エストラジオール (esutorajiōru)Translations
Polish estradiol
  • estradiolTranslations
Portuguese estradiol
  • estradiolTranslations
Russian эстрадио́л
  • эстрадио́л (estradiól)Translations
Slovak estradiol
  • estradiolTranslations
Swedish östradiol
  • östradiolTranslations
Turkish östradiol
  • östradiolTranslations

Rhymes & wordplay

Anagrams

steroidalidolastre
Cite this entry
APA

estradiol. (n.d.). In WatkinsX Dictionary. Retrieved November 3, 2026, from https://dictionary.watkinsx.com/word/estradiol

MLA

“estradiol.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/estradiol. Accessed November 3, 2026.

Chicago

WatkinsX Dictionary, s.v. “estradiol,” accessed November 3, 2026, https://dictionary.watkinsx.com/word/estradiol.

Source: estradiol on Wiktionary, CC BY-SA 4.0.