general paresis of the insane

noun

A neuropsychiatric disorder caused by late-stage syphilis, and characterized by fatigue, headaches, insomnia, personality changes, delusions, etc.

Similar
general paralysis of the insaneparalytic dementia
First used 19th c.
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Meanings

noungeneral paresis of the insane (uncountable)

alternative general paresis · alternative GPI

  1. uncountablemedicineA neuropsychiatric disorder caused by late-stage syphilis, and characterized by fatigue, headaches, insomnia, personality changes, delusions, etc.First known use 19th c.

    General paresis was described in 1822 by Antoine Laurent Bayle (1799–1858).

    1997, Roy Porter, The Greatest Benefit to Mankind, Folio Society, published 2016, page 487

    Synonyms: general paralysis of the insane, paralytic dementia

Synonyms & antonyms

nounA neuropsychiatric disorder caused by late-stage syphilis, and characterized by fatigue, headaches, insomnia, personality changes, delusions, etc.

Similar
general paralysis of the insaneparalytic dementia
Also see
general paralysisgeneral paralysis of the insaneparalytic dementia

Translations

Catalan paràlisi general de la demència
  • paràlisi general de la demèncianeuropsychiatric disorder caused by syphilis
Cite this entry
APA

general paresis of the insane. (n.d.). In WatkinsX Dictionary. Retrieved November 5, 2026, from https://dictionary.watkinsx.com/word/general%20paresis%20of%20the%20insane

MLA

“general paresis of the insane.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/general%20paresis%20of%20the%20insane. Accessed November 5, 2026.

Chicago

WatkinsX Dictionary, s.v. “general paresis of the insane,” accessed November 5, 2026, https://dictionary.watkinsx.com/word/general%20paresis%20of%20the%20insane.

Source: general paresis of the insane on Wiktionary, CC BY-SA 4.0.