haemoglobinopathy

plural haemoglobinopathies · alternative hemoglobinopathy

1. UKcountableuncountablemedicineAny of a group of inherited disorders in which haemoglobin does not function properly

   The clinical phenotypes of over 125 different hemoglobinopathies were interpreted in terms of structural alterations in globin structure.

   2016 December 19, Emmanuel Bissé et al., “Hemoglobin Kirklareli (α H58L), a New Variant Associated with Iron Deficiency and Increased CO Binding”, in Journal of Biological Chemistry, →DOI, page 2548

   2 more examples

   Simpler tools for detecting sickle haemoglobin made analysis of the malaria hypothesis in the context of this haemoglobinopathy that much easier, which has facilitated measurement of the trait against a spectrum of endpoints of protection, such as the infection itself, parasite density in infection, uncomplicated disease, and severe disease, and death.

   1996 December 7, Geoffrey Pasvol, “Malaria and resistance genes—they work in wondrous ways”, in The Lancet, volume 348, number 9041, →DOI, page 1533

   Active group membership was operationalized as having attended at least one group meeting during the past year, requesting voluntary inclusion on the group’s roster, and having been formally diagnosed with SCD or a related hemoglobinopathy.

   2000 February 28, Joseph Telfair, Marilyn Gardner, “Adolescents with Sickle Cell Disease: Determinants of Support Group Attendance and Satisfaction”, in Health & Social Work, →DOI, page 44