histotope

plural histotopes

1. The portion of an antigen that reacts with or binds to a T-cell.

   Thus, a mutation affecting the structure of a class II molecule changes the co-recognition specificity of a histotope on the APC of the mutant.

   1984, William E. Paul, Immunogenetics, page 156

   2 more examples

   However, this experiment by itself did not distinguish whether the change was in the desetope, which is the most straightforward interpretation, or in the histotope.

   2012, Benvenuto Pernis, Processing and Presentation of Antigens, page 117

   First, during ontogeny, T cells are positively selected by recognition of the histotope and then negatively selected by a tolerance mechanism or vice versa.

   2012, Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Ir Genes: Past, Present, and Future, page 303