hyperexpression

Since IL-10 and deficient co-stimulatory molecule expression appear to be a novel mechanism of self-tolerance employed by the pre-naïve B cells, a defect in pre-naïve B-cell functions could lead to a break in self-tolerance, especially in the SLE milieu, where expansion of the pre-naïve B cells has been found, and the immune system is intensely activated as evidenced by elevated B cell-activating factor (BAFF) levels, hyperexpression of CD40L on T cells, and/or increased levels of certain cytokines such as IL-21.

2015 July 25, Ji Hyun Sim et al., “Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus”, in Arthritis Research & Therapy, volume 17, →DOI