inoculate

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UK/ɪˈnɒkjuleɪt/US/ɪˈnɑːkjuleɪt/UK/ɪˈnɒkjulɪt/US/ɪˈnɑːkjulɪt/

verb

To introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease.

“to inoculate a tree”

UncommonFirst used c. 1722Scrabble 11

Meanings

inoculate1

verbinoculate (third-person singular simple present inoculates, present participle inoculating, simple past and past participle inoculated)

present singular third person inoculates · participle present inoculating · participle past inoculated · past inoculated · alternative innoculate

  1. transitiveimmunologyTo introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease.First known use c. 1722

    The sense that it takes outrageous fortune to get inoculated echoes here in the Bay Area, where pharmacies have canceled flu-shot clinics, doctors turn away pleading patients and health officials are reduced to telling panicked callers that they should practice good personal hygiene.

    2004 October 29, Marco R. Della Cava, “Vaccine shortage pricks tempers”, in Statesman Journal, volume 152, number 214, Salem, OR, page 2A
    1 more example

    But you would not willingly thus give up the Cause; therefore endeavour to draw others into your Assistance, and venture to assert, that by the Account Dr. Nettleton gives, as also by the best Observation upon those who have been Inoculated in this City, scarcely a fourth part of them have had a true and genuine Small Pox.

    1722, John Crawford, The Case of Inoculating the Small-pox Consider'd: And Its Advantages Asserted; in a Review of Dr. Wagstaffe's Letter. Wherein Every Thing that Author Has Advanced Against It, is Fully Confuted: and Inoculation Proved a Safe, Beneficial, and Laudable Practice.

    Synonyms: immunize, vaccinate, vaccine

  2. broadlytransitiveTo safeguard or protect something as if by inoculation.

    Her upbringing overseas inoculated her against prejudice.

    2 more examples

    This made it possible for them to enjoy the media without personally changing their views in ways that they believed it changed the views of others. In a sense, they believed that their religion inoculated them against the media's negative effects.

    2005 October 27, Lynn Schofield Clark, From Angels to Aliens: Teenagers, the Media, and the Supernatural, Oxford University Press, →ISBN, page 20

    Lenihan insisted that, given their history both as a former colony and a net exporter of people round the world, the Irish were better inoculated against racism and xenophobia than other EU nations[…]

    2011 November 7, Guy Arnold, Migration: Changing the World, Pluto Books, →ISBN
  3. transitiveTo add one substance to another.

    The culture medium was inoculated with selenium to investigate the rate of uptake.

    Synonyms: spike

  4. transitiveTo graft by inserting buds.First known use c. 1420

    to inoculate a tree

    2 more examples

    to inoculate the bud of one tree or plant into another

    And in Aprill figtreen inoculate

    c. 1420, anonymous author, edited by Barton Lodge, On husbondrie, Published for the Early English Text Society, by N. Trübner & Co., translation of original by Rutilius Taurus Aemilianus Palladius, published 1872
  5. figurativelytransitiveTo introduce into the mind (used especially of harmful ideas or principles).First known use a. 1600

    to inoculate someone with treason or infidelity

    2 more examples

    You ſhould not haue beleeu'd me, for vertue cannot ſo e[n]oculat our old ſtock, but vve ſhall reliſh of it, I loued you not.

    c. 1599–1602 (date written), William Shakespeare, The Tragicall Historie of Hamlet, Prince of Denmarke: […] (Second Quarto), London: […] I[ames] R[oberts] for N[icholas] L[ing] […], published 1604, →OCLC, [Act III, scene i], signature G2, verso

    The Church tries to inoculate humanity with the imaginary goodness drawn down from a fabulous heaven, and from a priest-manufactured God.

    1860, John Watts, The Christian Doctrine of Man's Depravity Refuted, Watts & Company, page 14

    Synonyms: imbue, implant

inoculate2

nouninoculate (plural inoculates)

plural inoculates · alternative innoculate

  1. Synonym of inoculum.

    Synonyms: inoculum

Synonyms & antonyms

verbTo introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease.

verbTo add one substance to another.

Similar

verbTo introduce into the mind (used especially of harmful ideas or principles).

nounSynonym of inoculum.

Similar

More synonyms by meaning

verbperform vaccinations or produce immunity in by inoculation

Synonym sets from Open English WordNet, CC BY 4.0.

Origin

inoculate · verb

  1. Latininoculātus
  2. Middle Englishinoculaten“to graft”
  3. Englishinoculate

First attested in c. 1440; inherited from Middle English inoculaten (“to graft”), from Latin inoculātus, perfect passive participle of inoculō (“to ingraft an eye or bud of one plant into (another), implant”) (see -ate (verb-forming suffix)), from in- (“in”) + oculus (“an eye”) + -ō (verb-forming suffix).

Full word history & related roots →

inoculate · noun

Back-formation from inoculation, see -ate (noun-forming suffix).

Full word history & related roots →

Translations

Arabic لَقَّحَ
  • لَقَّحَ (laqqaḥa)to provide immunity
Bulgarian ваксинирам, ваксинирам
  • ваксинирам (vaksiniram)to provide immunity
  • ваксинирам (vaksiniram)to safeguard as if by inoculation
  • ашладисвам (ašladisvam)to graft by inserting buds
  • внушавам (vnušavam)to introduce into the mind
Catalan inocular
  • inocularto provide immunity
Dutch inenten, inoculeren
  • inentento provide immunity
  • inoculerento add one substance to another
  • entento add one substance to another
Esperanto inokuli
  • inokulito provide immunity
Finnish rokottaa, rokottaa
  • rokottaato provide immunity
  • rokottaato safeguard as if by inoculation
  • lisätäto add one substance to another
  • silmuttaato graft by inserting buds
  • saastuttaato introduce into the mind
French inoculer
  • inoculerto provide immunity
German impfen, inokulieren
  • impfento provide immunity
  • inokulierento provide immunity
  • okulierento graft by inserting buds
  • äugelnto graft by inserting buds
Greek εμβολιάζω
  • εμβολιάζω (emvoliázo)to provide immunity
Māori oka
  • okato provide immunity
Portuguese inocular
  • inocularto provide immunity
Russian привива́ть, приви́ть
  • привива́ть (privivátʹ)to provide immunity
  • приви́ть (privítʹ)to provide immunity
Slovak očkovať, zaočkovať
  • očkovaťto provide immunity
  • zaočkovaťto provide immunity
  • štepiťto graft by inserting buds
  • zaštepiťto graft by inserting buds
  • naočkovaťto introduce into the mind
  • naočkovávaťto introduce into the mind
Spanish inocular
  • inocularto provide immunity
Swedish inokulera, ympa
  • inokulerato provide immunity
  • ympato provide immunity
  • inympato add one substance to another
  • inokulerato add one substance to another
Vietnamese chích ngừa, tiêm chủng
  • chích ngừato provide immunity
  • tiêm chủngto provide immunity
  • chíchto provide immunity
  • chủngto provide immunity
  • chủng ngừato provide immunity
  • tiêm phòngto provide immunity

Rhymes & wordplay

Anagrams

Cite this entry
APA

inoculate. (n.d.). In WatkinsX Dictionary. Retrieved November 3, 2026, from https://dictionary.watkinsx.com/word/inoculate

MLA

“inoculate.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/inoculate. Accessed November 3, 2026.

Chicago

WatkinsX Dictionary, s.v. “inoculate,” accessed November 3, 2026, https://dictionary.watkinsx.com/word/inoculate.

Source: inoculate on Wiktionary, CC BY-SA 4.0.