lipointoxicate

present singular third person lipointoxicates · participle present lipointoxicating · participle past lipointoxicated · past lipointoxicated

1. biochemistryTo disturb the biochemistry of a cell by the accumulation of saturated phospholipids.

   Lipointoxicated bronchial epithelial cells display aberrant, highly ordered, internal membranes.

   2018 September, Linette Kadria, Romain Ferru-Clémenta, Amélie Baclea, Laurie-Anne Payet, Anne Cantereau, Reynald Hélye, Frédéric Becq, Christophe Jayle, Clarisse Vandebrouck, Thierry Ferreira, “Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases”, in Molecular Basis of Disease, volume 1864, number 9

   2 more examples

   Overall, these data suggest that bronchial epithelial cells are lipointoxicated by hypoxia-related Palmitate accumulation in CF patients.

   2014 February, Laurie-Anne Payet, Linette Kadri, Sébastien Giraud, Caroline Norez, Jean Marc Berjeaud, Christophe Jayle, Sandra Mirval, Frédéric Becq, Clarisse Vandebrouck, Thierry Ferreira, “Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation”, in PloS one

   A particularly preferred compound according to the invention is mannide monooleate, the inventors of which have shown, using mammalian pancreatic β-cells lipointoxicated by saturated fatty acids, that it is advantageously able to increase insulin secretion in subjects suffering from lipointoxication and/or type 2 diabetes mellitus by promoting in said subjects the maturation of proinsulin to insulin.

   2016, Miroslava Spanova, Thierry Ferreira, Romain Clement, Shalinee Dhayal, Noël Morgan, Compounds and compositions comprising such compounds for the prevention or treatment of dyslipidaemias (US Patent application US20160256429A1)