midneurogenesis

An increase in nonvertical cleavage plane orientation of mouse aRG has been observed both upon knock-down of Spag5 and when Spag5 mRNA and protein levels in Pax6 mutant mice at midneurogenesis are elevated [ 47 ], suggesting that either too low or too high Spag5 levels perturb the normal, horizontal spindle orientation that is required for aRG vertical cleavage plane orientation.

2015 August 7, Fong Kuan Wong et al., “Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex”, in PLoS Biology, volume 13, →DOI