multichaperone

plural multichaperones

1. biochemistryA chaperone consisting of multiple proteins

   1 more example

   The complex containing Cdc37 and p23 is thought to be the primary stable form, and the HSP70- and HOP-associated complex is another proteasome-targeting form that induces ubiquitin-proteasome degradation [45, 46 ]. 17-AAG is an ansamycin antibiotic that binds to HSP90 and inhibits the formation of the stabilized HSP90-client protein complex, resulting in the accumulation of the proteasome-targeting HSP90-based multichaperone.

   2015 September 29, “The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein”, in PLOS ONE, →DOI