myddosome

plural myddosomes

1. A complex of signalling proteins that has a role in the immune response

   1 more example

   This signaling complex, the so-called myddosome, assembles in a hierarchical manner so that IRAKs can associate with tumor necrosis factor receptor-associated factor 6 (TRAF6), which, via a complex signaling cascade, ultimately enables NF-κB to translocate into the nucleus where it regulates gene transcription.

   2016 January 12, “Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice”, in PLOS ONE, →DOI