nonageable

Classic neuropathic OPs, such as diisopropyl fluorophosphate (DFP), are considered strong agonists since they cause OPIDP with 70% NTE inhibition, whereas nonageable inhibitors, such as CMs and sulfonyl fluorides, are considered partial agonists and therefore are among the weakest at initiating OPIDP requiring almost 100% NTE inhibition.

2011, Ramesh C Gupta, Toxicology of Organophosphate and Carbamate Compounds, page 362

Although the extensive SAR and QSAR studies on NTE inhibitors provided partial support for the theory that both inhibition and aging of NTE were required to precipitate OPIDN, the more convincing evidence came from experiments showing that pretreatement with nonageable NTE inhibitors protected against OPIDN from subsequent challenge with an ageable NTE inhibitor.

2020, Rudy J. Richardson, John K. FInk, Paul Glynn, Robert B. Hufnagel, Galina F. Makhaeva, Sanjeeva J. Wijeyesakere, “Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN)”, in Neurotoxicity of Pesticides, page 36