nonionizable

In fact, dutasteride has nonionizable groups with the pH-independent solubility profiles (pH 1–12). 21 However, the physical mixture exhibited an extremely low dissolution of less than 5% in all types of dissolution medium due to the poor solubility of dutasteride.

2015 June 23, In-hwan Baek et al., “Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride”, in Drug Design, Development and Therapy, volume 9, →DOI