overduplication

Cyclin E siRNA did not change the number of cells with a 4C DNA content after Orc1-1 treatment (fig. S13B), which implies that the block of centrosome overduplication in Orc1-1–depleted cells by Cyclin E siRNA was not due to a compete G1 arrest.

2009 February 6, Adriana S. Hemerly et al., “Orc1 Controls Centriole and Centrosome Copy Number in Human Cells”, in Science, volume 323, number 5915, →DOI, pages 789–793