paroxysmal nocturnal hemoglobinuria

noun

A rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.

Similar
Marchiafava–Micheli syndrome
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Meanings

nounparoxysmal nocturnal hemoglobinuria (uncountable, abbreviation PNH)

abbreviation PNH · alternative UK paroxysmal nocturnal haemoglobinuria

  1. uncountablemedicineA rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.

    Synonyms: Marchiafava–Micheli syndrome

Synonyms & antonyms

nounA rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.

Similar
Marchiafava–Micheli syndrome
Also see
marchiafava–micheli syndrome
Cite this entry
APA

paroxysmal nocturnal hemoglobinuria. (n.d.). In WatkinsX Dictionary. Retrieved November 5, 2026, from https://dictionary.watkinsx.com/word/paroxysmal%20nocturnal%20hemoglobinuria

MLA

“paroxysmal nocturnal hemoglobinuria.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/paroxysmal%20nocturnal%20hemoglobinuria. Accessed November 5, 2026.

Chicago

WatkinsX Dictionary, s.v. “paroxysmal nocturnal hemoglobinuria,” accessed November 5, 2026, https://dictionary.watkinsx.com/word/paroxysmal%20nocturnal%20hemoglobinuria.

Source: paroxysmal nocturnal hemoglobinuria on Wiktionary, CC BY-SA 4.0.