polypill

plural polypills

1. medicineMedication that is a combination drug of at least four active ingredients; especially, one that is intended to be consumed widely, even by currently healthy individuals, as a means of preventive medicine.

   Synonyms: combopill, SPC

   1. oftenspecificallymedicineAny of a class of such pills for reduction of cardiovascular risk, some for primary prevention of cardiovascular disease in healthy people and some for secondary prevention (preventing strokes and heart attacks) in those who already have cardiovascular disease.

      1 more example

      A polypill containing a beta-blocker, a mineralocorticoid antagonist, and an SGLT2 inhibitor produced a substantial improvement in compliance to guideline-directed medical therapy for heart failure along with measurable improvements in heart failure control, according to data from a randomized trial [the POLY-HF trial]. Compared with usual care, the polypill was associated with increases in adherence and left ventricular ejection fraction (LVEF) as well as a reduction in hospitalizations over a 6-month period […] [The interviewed physicians] pointed out that most studies show less than half of heart failure patients on optimized doses of all guideline-directed medical therapy. It is not clear that a polypill is the only or best answer to this chronic problem, but Prabhakaran said POLY-HF supports the polypill as “an attractive option.” “These are particularly encouraging results while we wait for hard endpoint trials,” he said.

      2025 November 18, Ted Bosworth, “Polypill Improves Cardiac Function, Clinical Outcomes in HFrEF”, in Medscape

      Synonyms: combopill, SPC