Meanings
smoothened1
- participlepastsimple past and past participle of smoothen
comparative more smoothened · superlative most smoothened
- Having been made smooth.
Antonyms: unsmoothened
smoothened2
alternative Smoothened
- uncountablebiochemistryA transmembrane protein belonging to the group of G protein-coupled receptors that is a key component of the hedgehog signaling pathway.
Synonyms: Smo
Synonyms & antonyms
adjectiveHaving been made smooth.
nounA transmembrane protein belonging to the group of G protein-coupled receptors that is a key component of the hedgehog signaling pathway.
More synonyms by meaning
Synonym sets from Open English WordNet, CC BY 4.0.
Origin
smoothened · noun
Ultimately the same as etymology 1. The gene encoding the protein was first identified in Drosophila melanogaster as a segment polarity gene and initially named smooth (smo) by Christiane Nüsslein-Volhard et al. in 1984. This was later revised to smoothened by Dan L. Lindsley and Georgianna G. Zimm in 1992, because the former name already described another locus.
Full word history & related roots →Cite this entry
smoothened. (n.d.). In WatkinsX Dictionary. Retrieved November 3, 2026, from https://dictionary.watkinsx.com/word/smoothened
“smoothened.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/smoothened. Accessed November 3, 2026.
WatkinsX Dictionary, s.v. “smoothened,” accessed November 3, 2026, https://dictionary.watkinsx.com/word/smoothened.
Source: smoothened on Wiktionary, CC BY-SA 4.0.