terephthalamides

Additionally, the compound exhibits inhibitory effects on tumor growth in mouse models ( 41 ).[ 390 ] Notably, terephthalamides also disrupted the BAK–BCL-xL complex formation in human cell culture.[ 304, 405 ] NMR spectroscopy and computational studies proved binding to the same cleft as the BAK BH3 peptide.

2015 June 26, Marta Pelay-Gimeno et al., “Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes”, in Angewandte Chemie (International Ed. in English), volume 54, →DOI