tolbutamide

plural tolbutamides

1. countableuncountableA drug that blocks potassium channels, used in the treatment of diabetes.

   The cryophilic phenotype of the atu mutant was alleviated to some extent by administering rotenone, a pharmacological inhibitor of oxidative phosphorylation, but not tolbutamide, a sulphonylurea that stimulates metabolic rate by raising the lymphatic concentration of glucose.

   2009 March 27, Ken-ichi Takeuchi et al., “Changes in Temperature Preferences and Energy Homeostasis in Dystroglycan Mutants”, in Science, volume 323, number 5922, →DOI, pages 1740–1743