The story
CHAPLE stands for "CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and severe protein-losing enteropathy".
Etymology from Wiktionary, CC BY-SA 4.0.
CHAPLE syndrome
Today it means: A rare genetic disorder of the immune system, caused by mutations of the complement regulator CD55 gene, and characterized by severe protein-losing enteropathy leading to hypoproteinemia. Full definition →