CHAPLE syndrome

noun

A rare genetic disorder of the immune system, caused by mutations of the complement regulator CD55 gene, and characterized by severe protein-losing enteropathy leading to hypoproteinemia.

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Meanings

nounCHAPLE syndrome (uncountable)
  1. uncountableA rare genetic disorder of the immune system, caused by mutations of the complement regulator CD55 gene, and characterized by severe protein-losing enteropathy leading to hypoproteinemia.

Origin

CHAPLE stands for "CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and severe protein-losing enteropathy".

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Cite this entry
APA

CHAPLE syndrome. (n.d.). In WatkinsX Dictionary. Retrieved November 4, 2026, from https://dictionary.watkinsx.com/word/CHAPLE%20syndrome

MLA

“CHAPLE syndrome.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/CHAPLE%20syndrome. Accessed November 4, 2026.

Chicago

WatkinsX Dictionary, s.v. “CHAPLE syndrome,” accessed November 4, 2026, https://dictionary.watkinsx.com/word/CHAPLE%20syndrome.

Source: CHAPLE syndrome on Wiktionary, CC BY-SA 4.0.