Etymology

a whole nother

Today it means: An intensified form of another: an entirely different; a whole other. Full definition →

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The story

Either from a + whole + nother (“different, other”), where nother is a variant of other, rebracketed from an other, or from whole + another, with whole having been inserted by tmesis. Compare also dialectal tother from Middle English þe toþer (“the other”).

Etymology from Wiktionary, CC BY-SA 4.0.