Etymology

my brother in Christ

Today it means: A (sometimes condescending) term of address, used before a statement which intends to dispel someone's lack of self-awareness. Full definition →

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The story

From my + brother in Christ. The phrase was in use unironically for softening the delivery of a harsh truth and discouraging the shooting of the messenger before it ever was used sarcastically as an internet meme; it pursued those aims by emphasizing spiritual fraternity between speaker and listener (compare the theme of all due respect and you know I love you, but you need to hear the truth).

Etymology from Wiktionary, CC BY-SA 4.0.