Tsuji-Trost reaction

noun

A palladium-catalysed substitution reaction involving a substrate that contains a leaving group in an allylic position. The palladium catalyst first coordinates with the allyl group and then undergoes oxidative addition, forming the π-allyl complex. This allyl complex can then be attacked by a nucleophile, resulting in the substituted product.

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Meanings

nounTsuji-Trost reaction (plural Tsuji-Trost reactions)

plural Tsuji-Trost reactions

  1. chemistryA palladium-catalysed substitution reaction involving a substrate that contains a leaving group in an allylic position. The palladium catalyst first coordinates with the allyl group and then undergoes oxidative addition, forming the π-allyl complex. This allyl complex can then be attacked by a nucleophile, resulting in the substituted product.

Origin

Pioneered by Jiro Tsuji in 1965 and later adapted by Barry Trost in 1973 with the introduction of phosphine ligands.

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Cite this entry
APA

Tsuji-Trost reaction. (n.d.). In WatkinsX Dictionary. Retrieved November 5, 2026, from https://dictionary.watkinsx.com/word/Tsuji-Trost%20reaction

MLA

“Tsuji-Trost reaction.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/Tsuji-Trost%20reaction. Accessed November 5, 2026.

Chicago

WatkinsX Dictionary, s.v. “Tsuji-Trost reaction,” accessed November 5, 2026, https://dictionary.watkinsx.com/word/Tsuji-Trost%20reaction.

Source: Tsuji-Trost reaction on Wiktionary, CC BY-SA 4.0.