citrullination

plural citrullinations

1. biochemistryThe posttranslational modification of the amino acid arginine in a protein into the amino acid citrulline.

   In MS citrullination is the most studied PTM^([post-translational modification]) from those listed in Table 6.1.

   2017, Alastair Wilkins, Progressive Multiple Sclerosis, 2nd edition, Springer, page 141

   2 more examples

   Naturally occurring/substituted amino acids, flanking targeted arginine, influence its susceptibility to citrullination by peptidylarginine deiminases.

   2017, B. Amin, W. Voelter, “Human Deiminases”, in A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, editors, Progress in the Chemistry of Organic Natural Products, Volume 106, Springer, page 220

   2019, Shuzheng Song, Yingyan Yu, Progression on Citrullination of Proteins in Gastrointestinal Cancers, Zhe-Sheng Chen, Jian-ye Zhang, Yunkai Zhang, Yan-yan Yan (editors), Targeted Cancer Therapies, From Small Molecules to Antibodies, Frontiers Media, page 162, The exact effect of citrullination of proteins on cancer should be studied further. Citrullination of proteins is not only detected in in vitro experiments, but also in human blood.

   Synonyms: deimination