immunosenescent

Restoration of response to vaccination in immunosenescent aged mice by CASAC likely reflects the benefits of multiple TLR triggering on DC function [ 14, 24, 25 ] and provision of IFN-γ could substitute for lack of IFN-γ from CD8+ memory cells during the early phase of immune response.

2015 June 25, Gee Jun Tye et al., “The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice”, in Immunity & Ageing : I & A, volume 12, →DOI