depressant

D2E1P3R1E1S1S1A1N1T1
UK, US/dɪˈpɹɛsənt/

noun

A pharmacological substance which decreases neuronal or physiological activity.

“Alcohol acts first as a stimulant and then as a depressant.”

Opposite
Less commonScrabble 13

Meanings

noundepressant (countable and uncountable, plural depressants)

plural depressants

  1. countableuncountablemedicineA pharmacological substance which decreases neuronal or physiological activity.

    Alcohol acts first as a stimulant and then as a depressant.

    2 more examples

    The prescription painkiller Emily Jackson took is a respiratory depressant that slows breathing. That in combination with the alcohol, another respiratory depressant, overwhelmed her brain, which stopped giving her heart and lungs the signal to keep functioning.

    2012 November 15, Maxwell Newfield, “Prescription drug deaths: Two stories”, in CNN

    On the opposite end of the drug side effect spectrum are downers. This slang term refers to CNS depressants, the types of drugs that produce a sedative effect by slowing down the messages sent and received between the central nervous system and the brain.

    2024 April 10 [2020 August 27], Nick B., “Which Drugs Are Uppers And Downers?”, in The Freedom Center
  2. countableuncountablebusinessAn agent that inhibits the flotation of a mineral or minerals.
adjectivedepressant (comparative more depressant, superlative most depressant)

comparative more depressant · superlative most depressant

  1. medicineReducing functional or nervous activity.

    the conception of the asomatous depressant malaria

    1876, Alfred Alexander Woodhull, Studies, chiefly clinical […]

Synonyms & antonyms

adjectivecapable of depressing physiological or psychological activity or response by a chemical agent

Opposite

nouna drug that reduces excitability and calms a person

Similar
sedativesedative drugdowner

Synonym sets from Open English WordNet, CC BY 4.0.

Origin

Translations

Chinese Mandarin 镇静剂
  • 镇静剂 (zhènjìngjì)substance which decreases physiological activity
Finnish depressantti, lamaute
  • depressanttisubstance which decreases physiological activity
  • lamautesubstance which decreases physiological activity
Hindi अवनमक, अवसादक
  • अवनमक (avanmak)substance which decreases physiological activity
  • अवसादक (avsādak)substance which decreases physiological activity
Indonesian penenang, depresan
  • penenangsubstance which decreases physiological activity
  • depresansubstance which decreases physiological activity
Irish dúlagrán
  • dúlagránsubstance which decreases physiological activity
Korean 억제제
  • 억제제 (eokjeje)substance which decreases physiological activity
Malay ڤننڠ, depresen
  • ڤننڠ (penenang)substance which decreases physiological activity
  • depresensubstance which decreases physiological activity
Māori pūroi haupēhi
  • pūroi haupēhisubstance which decreases physiological activity
Persian سرکوبکننده
  • سرکوبکننده (sarkub-konande)substance which decreases physiological activity
Welsh iselydd
  • iselyddsubstance which decreases physiological activity

Rhymes & wordplay

Rhymes with depressant

All rhymes →

Anagrams

Cite this entry
APA

depressant. (n.d.). In WatkinsX Dictionary. Retrieved November 4, 2026, from https://dictionary.watkinsx.com/word/depressant

MLA

“depressant.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/depressant. Accessed November 4, 2026.

Chicago

WatkinsX Dictionary, s.v. “depressant,” accessed November 4, 2026, https://dictionary.watkinsx.com/word/depressant.

Source: depressant on Wiktionary, CC BY-SA 4.0.