midthermia

Perhaps a compromise between near normothermic temperatures and the typical 4°C perfusion would be best for clinical use. Here the warmer temperatures at midthermia (15–20°C) may promote metabolic repair but remain cool enough to suppress metabolism and slow reactions and flow rates so that machine automation can be practical for clinical use.

2009 July 1, Charles Y Lee, Martin J Mangino, “Preservation methods for kidney and liver”, in Organogenesis, volume 5, number 3, →DOI, archived from the original on 19 Nov 2022, pages 105-112

Notwithstanding that cell culture experiments from Rauen et al have demonstrated that the majority of cell damage, induced by rapid warming up of the medium are only observed upon transition from hypo- to midthermia (between 8 and 16°C), suggesting the “rewarming injury” to be operative predominantly at temperatures below approximately 16°C.²²

2017 September 4, Charlotte von Horn, Hideo A. Baba, Patrik Hannaert, Thierry Hauet, Henri Leuvenink, Andreas Paul, Thomas Minor, “Controlled oxygenated rewarming up to normothermia for pretransplant reconditioning of liver grafts”, in Clinical Transportation, volume 31, number 11, →DOI, archived from the original on 03 Jun 2025, page 5