oversialylated

While it would be interesting to test whether prion disease is delayed in Neu1 knockout mice, these mice, unfortunately, do not have a sufficient lifespan, as they suffer from sialidosis, muscle degeneration and Alzheimer’s disease-like amyloidogenic processing of an oversialylated amyloid precursor protein in lysosomes [60, 63, 64 ].

2015 November 17, “Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1”, in PLOS ONE, →DOI