phosphodegron

plural phosphodegrons

1. A phosphorylated degron

   Activated Nek11 is capable of phosphorylating Cdc25A on sites within a phosphodegron that promotes recruitment of β-TrCP. This, in turn, leads to ubiquitin-mediated degradation of Cdc25A and cell cycle arrest [11 –13 ].

   2015 October 27, “Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents”, in PLOS ONE, →DOI