pyrophosphorylysis

plural pyrophosphorylyses

1. The cleavage of a nucleoside from a nucleotide by breaking the bond to the phosphate group by a reaction with pyrophosphorylase.

   Increased pyrophosphorylysis means that newly incorporated nucleotides, including potentially chain-terminating nucleotide analogues, are excised at a higher rate.

   2002, Advances in Virus Research - Volume 58, page 170

   2 more examples

   The enzyme preparations were assay for ADPglucose pyrophosphorylase activity in the pyrophosphorylysis direction and were diluted to 0.5 units per ml with 50 mM Tris-HCl, pH 8.0, containing O. l mg/ml of bovine plasma pyrophosphorylase.

   1986, Patrick Sai-Cheong Leung, Cloning of the Salmonella Typhimurium LT2 Glycogen Biosynthetic Genes

   Although the DKAs and dihydroxypyrimidines can compete with nucleosides for binding to the active site, these compounds inhibit the pyrophosphorylysis (excision) of strand-terminating nucleosides once they are incorporated into the nascent HCV RNA.

   2017, Douglas L. Mayers, Jack D. Sobel, Marc Ouellette, Antimicrobial Drug Resistance, →ISBN